Potent, selective inhibitor of iNOS
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N-Benzylacetamidine (hydrobromide)

Item No. 13570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(phenylmethyl)-ethanimidamide, monohydrobromide
CAS Number
186545-76-6
Molecular Formula
C9H12N2 • HBr
Formula Weight
229.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(NCC1=CC=CC=C1)=N.Br
InChi Code
InChI=1S/C9H12N2.BrH/c1-8(10)11-7-9-5-3-2-4-6-9;/h2-6H,7H2,1H3,(H2,10,11);1H
InChi Key
RUQJDXJQOUUQHG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $72

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    10 mg

    $134

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    50 mg

    $556

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    100 mg

    $973

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    Product Description

    Of the different types of nitric oxide synthases (NOS), the inducible (iNOS) form contributes to inflammation and immune response while the constitutively-expressed endothelial (eNOS) enzyme plays important roles in regulating vascular tone. N-Benzylacetamidine is a potent inhibitor of iNOS (IC50 = 0.20 μM), with over 1,000-fold selectivity compared to eNOS (IC50 = 350 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maccallini, C., Patruno, A., Besker, N., et al. Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase. J. Med. Chem. 52(5), 1481-1485 (2009).