A prodrug of a DP receptor agonist
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AL 6598

Item No. 13620

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(3R)-3-cyclohexyl-3-hydroxypropyl]-3-hydroxycyclopentyl]-2-buten-1-yl]oxy]-acetic acid, 1-methylethyl ester
CAS Number
170291-06-2
Molecular Formula
C23H39ClO5
Formula Weight
431.0
Purity
≥97%
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/ml
SMILES
Cl[C@H]1[C@H](C/C=C\COCC(OC(C)C)=O)[C@@H](CC[C@@H](O)C2CCCCC2)[C@H](O)C1
InChi Code
InChI=1S/C23H39ClO5/c1-16(2)29-23(27)15-28-13-7-6-10-18-19(22(26)14-20(18)24)11-12-21(25)17-8-4-3-5-9-17/h6-7,16-22,25-26H,3-5,8-15H2,1-2H3/b7-6-/t18-,19-,20-,21-,22-/m1/s1
InChi Key
GXLUEHGRKZQLOO-QMAHXAMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $132

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    1 mg

    $256

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    5 mg

    $1,055

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    10 mg

    $1,842

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    Product Description

    Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an EC50 value of 0.80 µM in an in vitro functional assay.1 Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hellberg, M.R., Conrow, R.E., Sharif, N.A., et al. 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents. Bioorg. Med. Chem. 10(6), 2031-2049 (2002).