Risperidone

Risperidone is an atypical antipsychotic that binds to dopamine D₂ receptors (K_i = 3 nM) and the serotonin (5-HT) receptor subtype 5-HT_2A (K_i = 0.12 nM).^1,2 It also binds to dopamine D₄, α₁- and α₂-adrenergic, 5-HT_1C, 5-HT_1D, and histamine H₁ receptors (K_is = 7, 0.81, 7.3, 47, 52, and 2.1 nM, respectively). Risperidone (0.1 mg/kg per day, i.p.) attenuates deficits in prepulse inhibition of the acoustic startle response, but not deficits in social interaction, in a rat neonatal ventral hippocampal lesion model of schizophrenia.³ Formulations containing risperidone have been used in the treatment of schizophrenia and bipolar disorder.

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1. Leysen, J.E., Janssen, P.M., Gommeren, W., et al. In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Mol. Pharmacol. 41(3), 494-508 (1992).

2. Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14(2), 87-96 (1996).

3. Rueter, L.E., Ballard, M.E., Gallagher, K.B., et al. Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophrenia. Psychopharmacology (Berl.) 176(3-4), 312-319 (2004).