An antithrombic compound
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Aspalatone

Item No. 13644

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(acetyloxy)-2-methyl-4-oxo-4H-pyran-3-yl-benzoic acid ester
CAS Number
147249-33-0
Synonyms
  • Acetylsalicylic Acid Matol ester
Molecular Formula
C15H12O6
Formula Weight
288.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 1 mg/ml
λmax
237 nm
SMILES
O=C1C(OC(C2=C(OC(C)=O)C=CC=C2)=O)=C(C)OC=C1
InChi Code
InChI=1S/C15H12O6/c1-9-14(12(17)7-8-19-9)21-15(18)11-5-3-4-6-13(11)20-10(2)16/h3-8H,1-2H3
InChi Key
JVBIZYPCGNCWIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $73

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    50 mg

    $302

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    100 mg

    $525

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    Product Description

    Aspalatone is an anti-platelet aggregator (IC50 = 180 µM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism.1 Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, B.H., Suh, D.Y., Yang, H.O., et al. Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity. Arzneimittelforschung 44(10), 1122-1126 (1994).

    2. Kim, H.C., Choi, D.Y., Jhoo, W.K., et al. Aspalatone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic acid in the rat. Life Sci. 61(24), 373-381 (1997).

    Product Citations

    Sonowal, H., Pal, P.B., Shukla, K., et al. Aspalatone prevents VEGF-induced lipid peroxidation, migration, tube formation, and dysfunction of human aortic endothelial cells. Oxidative Medicine and Cellular Longevity 2017, 2769347 (2017).