Inhibitor of autotaxin (lysophospholipase D)
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S32826

Item No. 13664

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-phosphonic acid
CAS Number
1096770-84-1
Molecular Formula
C21H36NO4P
Formula Weight
397.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/ml
λmax
250 nm
SMILES
O=C(CCCCCCCCCCCCC)NC1=CC=C(CP(O)(O)=O)C=C1
InChi Code
InChI=1S/C21H36NO4P/c1-2-3-4-5-6-7-8-9-10-11-12-13-21(23)22-20-16-14-19(15-17-20)18-27(24,25)26/h14-17H,2-13,18H2,1H3,(H,22,23)(H2,24,25,26)
InChi Key
OUXAHVRWFHOKHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $132

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    10 mg

    $242

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    Product Description

    S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC50 of 8.8 nM.1 It shows similar effectiveness against the three known autotaxin isoforms (α, β, and γ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 μM) and phosphatase 1B (IC50 = 15 μM).1 S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ferry, G., Moulharat, N., Pradère, J.P., et al. S32826, a nanomolar inhibitor of autotaxin: Discovery, synthesis and applications as a pharmacological tool. J. Pharmacol. Exp. Ther. 327, 809-819 (2008).

    Product Citations

    Iyer, P., Lalane, R., III, Morris, C., et al. Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. PLoS One 7(8), e42627 (2012).