Inhibitor of Nampt
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GPP 78

Item No. 13670

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-1H-1,2,3-triazole-1-octanamide
CAS Number
1202580-59-3
Synonyms
  • CAY10618
  • NMPRTase Inhibitor
Molecular Formula
C27H29N5O
Formula Weight
439.6
Purity
≥95%
Formulation
A 5 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
234 nm
SMILES
O=C(NC1=C(C2=CC=CC=C2)C=CC=C1)CCCCCCCN3N=NC(C4=CC=CN=C4)=C3
InChi Code
InChI=1S/C27H29N5O/c33-27(29-25-16-9-8-15-24(25)22-12-5-4-6-13-22)17-7-2-1-3-10-19-32-21-26(30-31-32)23-14-11-18-28-20-23/h4-6,8-9,11-16,18,20-21H,1-3,7,10,17,19H2,(H,29,33)
InChi Key
SJOLTIOPWDLDEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $22

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    1 mg

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    5 mg

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    10 mg

    $283

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    Cayman Chemical
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    Product Description

    GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM).1 It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Colombano, G., Travelli, C., Galli, U., et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J. Med. Chem. 53(2), 616-623 (2010).

    2. Stein, R.L., Melandri, F., and Dick, L. Kinetic characterization of the chymotryptic activity of the 20S proteasome. Biochemistry 35, 3899-3908 (1996).