A 15-PGDH inhibitor
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CAY10638

Item No. 13695

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]-2,4-thiazolidinedione
CAS Number
1221413-57-5
Synonyms
  • Thiazolidinedione derivative
Molecular Formula
C16H13NO3S2
Formula Weight
331.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 25 mg/ml
λmax
234, 343 nm
SMILES
O=C(/C(S1)=C/C(C=C2)=CC=C2OCCC3=CC=CS3)NC1=O
InChi Code
InChI=1S/C16H13NO3S2/c18-15-14(22-16(19)17-15)10-11-3-5-12(6-4-11)20-8-7-13-2-1-9-21-13/h1-6,9-10H,7-8H2,(H,17,18,19)/b14-10-
InChi Key
NTKWOUHXDKSPIX-UVTDQMKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $219

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    25 mg

    $502

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    Product Description

    Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.1 Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review. Prostaglandins 12(4), 647-679 (1976).

    2. Owens, D.R. Thiazolidinediones. An pharmacological overview. Clin. Drug Investig. 22(8), 485-505 (2002).

    3. Wu, Y., Tai, H.H., and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. Bioorg. Med. Chem. 18(4), 1428-1433 (2010).