Methylated Lysine Polyclonal Antibody - Biotinylated

Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves methylation.¹ Lysine can be methylated once, twice, or three times by lysine methyltransferases. The transfer of methyl groups from S-adenosyl methionine to histones is catalyzed by enzymes known as histone methyltransferases. Histones which are methylated on certain residues can act epigenetically to repress or activate gene expression.^1,2

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1. Yang, X.J. Multisite protein modification and intramolecular signaling. Oncogene 24(10), 1653-1662 (2005).

2. Melcher, M., Schmid, M., Aagaard, L., et al. Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression. Mol. Cell Biol. 20(10), 3728-3841 (2000).