For immunochemical analysis of Akt1 (Phospho-Ser473)
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Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)

Item No. 13733

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
synthetic peptide from human Akt1 containing phospho-serine473
Clone Designation
104A282
Formulation (Request formulation change)
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Host
Mouse
Isotype
IgG2κ
Applications
IP and WB
Species Reactivity
(+) Human Akt1(+) Mouse Akt1
Origin
Animal/Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 ea

    $395

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    Product Description

    Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer, as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. Akt/PKB phosphorylation is critical for its activity. The major phosphorylation sites required for Akt activation have been identified as threoinine 308 and serine 473. Serine473 is phosphorylated by MAPKAP kinase 2.

    WARNING This product is not for human or veterinary use.