A free acid, 2-series analog of butaprost
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CAY10408

Item No. 13747

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-11α,16R-dihydroxy-17-cyclobutyl-5Z,13E-dien-1-oic acid
CAS Number
212310-16-2
Molecular Formula
C23H36O5
Formula Weight
392.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 25 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
CCCC1(CCC1)[C@H](O)C/C=C/[C@H]1C(O)CC(=O)C1C/C=C\CCCC(=O)O
InChi Code
InChI=1S/C23H36O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h3,5,7,10,17-18,20-21,25-26H,2,4,6,8-9,11-16H2,1H3,(H,27,28)/b5-3-,10-7+/t17-,18-,20-,21-/m1/s1
InChi Key
HJVBXPOYFHMZAS-QTUFFCAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $142

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    5 mg

    $640

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    10 mg

    $1,207

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    Product Description

    CAY10408 is a free acid, 2-series analog of butaprost. It is the less active C-16 epimer compared to the 16(S) isomer, which has the same stereochemistry as butaprost. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.1 Since the majority of reports related to butaprost utilize the methyl ester derivative,2,3 it may be some time before the precise pharmacology of the free acid compounds, like CAY10408, is reported.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lawrence, R.A., and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. Br. J. Pharmacol. 105(4), 817-824 (1992).

    2. Regan, J.W., Bailey, T.J., Pepperl, D.J., et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol. Pharmacol. 46(2), 213-220 (1994).

    3. Talpain, E., Armstrong, R.A., Coleman, R.A., et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. Br. J. Pharmacol. 114(7), 1459-1465 (1995).