A stable, potent analog of PGE1
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Labeled Version(s)
25416Limaprost-d3
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Limaprost

Item No. 13810

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α,15S-dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
CAS Number
74397-12-9
Synonyms
  • 17α,20-dimethyl-Δ2-PGE1
  • 17α,20-dimethyl-Δ2-Prostaglandin E1
Molecular Formula
C22H36O5
Formula Weight
380.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >30 mg/mlDMSO: >130 mg/mlEthanol: >50 mg/mlPBS (pH 7.2): >2 mg/ml
SMILES
O[C@H]1[C@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@@H](CCCC/C=C/C(O)=O)C(C1)=O
InChi Code
InChI=1S/C22H36O5/c1-3-4-9-16(2)14-17(23)12-13-19-18(20(24)15-21(19)25)10-7-5-6-8-11-22(26)27/h8,11-13,16-19,21,23,25H,3-7,9-10,14-15H2,1-2H3,(H,26,27)/b11-8+,13-12+/t16-,17+,18+,19+,21+/m0/s1
InChi Key
OJZYRQPMEIEQFC-UAWLTFRCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch. Int. Pharmacodyn. Ther. 247(1), 89-102 (1980).