An inducer of definitive endoderm from embryonic stem cells
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Stem Cell Research
Differentiation

IDE2

Item No. 13817

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-cyclopentylidenehydrazide)-heptanedioic acid
CAS Number
1136466-93-7
Molecular Formula
C12H20N2O3
Formula Weight
240.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 25 mg/mlEthanol: 0.1 mg/ml
λmax
233 nm
SMILES
OC(CCCCCC(N/N=C1CCCC\1)=O)=O
InChi Code
InChI=1S/C12H20N2O3/c15-11(8-2-1-3-9-12(16)17)14-13-10-6-4-5-7-10/h1-9H2,(H,14,15)(H,16,17)
InChi Key
CVYPYYPTFNVREL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $153

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    10 mg

    $222

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    Product Description

    IDE2 is a small molecule capable of inducing definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50 = 223 nM in vitro) by activating the TGF-β signaling pathway.1 IDE2-derived endodermal cells injected into E8.75 mouse embryos ex vivo have been shown to incorporate into the developing gut tube, contributing to its formation.1 Furthermore, when treated with either indolactam V (Item No. 14647) or a standard regimen of the growth factor FGF-10, retinoic acid, and hedgehog inhibitors, IDE2-induced endodermal cells can form Pdx1-expressing pancreatic progenitors.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Borowiak, M., Maehr, R., Chen, S., et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4(4), 348-358 (2009).