Pricing updated 2019-01-16. Prices are subject to change without notice.
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells.1 3-
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1. Simon, J.A., and Lange, C.A. Roles of the EZH2 histone methyltransferase in cancer epigenetics Mutation Research 647, 21-29 (2008).
Tseng, C.K.H., Marquez, V.E., Fuller, R.W., et al. Synthesis of 3-
Fiskus, W., Wang, Y., Sreekumar, A., et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-
4. Bissinger, E.M., Heinke, R., Sippl, W., et al. Targeting epigenetic modifiers: Inhibitors of histone methyltransferases Med.Chem.Commun. (2010).