IRAK1 Polyclonal Antibody

Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-α, and LPS. A serine/threonine protein kinase associated with interleukin-1 receptor-associated kinase 1 (IRAK1) and its homologue murine pelle-like protein kinase (mPLK) has been identified.^1,2 IRAK1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response.³ IRAK1 mediates a signaling cascade leading to NF-κB activation by members of the IL-1 family including IL-1 and IL-18 (also known as IGIF).^2,4

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1. Huang, J., Gao, X., Li, S., et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 94(24), 12829-12832 (1997).

2. Robinson, D., Shibuya, K., Mui, A., et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activated IRAK and NFκB. Immunity 7(4), 571-581 (1997).

3. Trofimova, M., Sprenkle, A.B., Green, M., et al. Developmental and tissue-specific expression of mouse pelle-like protein kinase. The Journal of Biological Chemisty 271(30), 17609-17612 (1996).

4. Cao, Z., Henzel, W.J., and Gao, X. IRAK: A kinase associated with the interleukin-1 receptor. Science 271(5252), 1128-1131 (1996).