An antimitotic agent
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Nocodazole

Item No. 13857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester
CAS Number
31430-18-9
Synonyms
  • NSC 238159
  • Oncodazole
  • R 17934
Molecular Formula
C14H11N3O3S
Formula Weight
301.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
214, 258, 315 nm
SMILES
O=C(C1=CC=CS1)C2=CC(N=C(NC(OC)=O)N3)=C3C=C2
InChi Code
InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChi Key
KYRVNWMVYQXFEU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Product Description

    Nocodazole is an antimitotic agent.1 It increases tubulin GTP hydrolysis four-fold and induces tubulin depolymerization.1,2 Nocodazole (4 µg/ml) halts the cell cycle in the mitotic phase and synchronizes WI38 cells in the G2/M phase.3 It also decreases neuronal mitochondrial transport and density in a transgenic zebrafish model with neurons expressing fluorescent proteins in mitochondrial and cell membranes when used at a concentration of 400 nM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mejillano, M.R., Shivanna, B.D., and Himes, R.H. Studies on the nocodazole-induced GTPase activity of tubulin. Arch. Biochem. Biophys. 336(1), 130-138 (1996).

    2. Thyberg, J., and Moskalewski, S. Role of microtubules in the organization of the Golgi complex. Exp. Cell Res. 246(2), 263-279 (1999).

    3. Lee, J.Y., Leonhardt, L.G., and Obeid, L.M. Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. Biochem. J. 334(Pt 2), 457-461 (1998).

    4. Plucińska, G., Paquet, D., Hruscha, A., et al. In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. J. Neurosci. 32(46), 16203-16212 (2012).