A potent and reversible inhibitor of ceramide kinase
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NVP-231

Item No. 13858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide
CAS Number
362003-83-6
Molecular Formula
C25H25N3O2S
Formula Weight
431.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 12 mg/mlEthanol: 1 mg/ml
λmax
224, 316 nm
SMILES
O=C(C1(C[C@@H](C2)C3)C[C@H]3CC2C1)NC4=CC(SC(NC(C5=CC=CC=C5)=O)=N6)=C6C=C4
InChi Code
InChI=1S/C25H25N3O2S/c29-22(18-4-2-1-3-5-18)28-24-27-20-7-6-19(11-21(20)31-24)26-23(30)25-12-15-8-16(13-25)10-17(9-15)14-25/h1-7,11,15-17H,8-10,12-14H2,(H,26,30)(H,27,28,29)/t15-,16-,17?,25?/m1/s1
InChi Key
MVSSJPGNLQPWSW-FGUCWDTJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    NVP-231 is a potent and reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 It is selective for ceramide kinase over SPHK1, SPHK2, DAGKa, PI3Ka, PI4Kb, VPS34, GCS, SMS-1, and CERT (IC50s = >5 mM). NVP-231 inhibits formation of ceramide-1-phosphate (C1P; IC50 = 10 nM) and cell death in ceramide kinase overexpressing COS cells (COS-CerK). It also inhibits C1P formation and tube formation in murine dermal microvascular endothelial cells when used at a concentration of 100 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Graf, C., Klumpp, M., Habig, M., et al. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol. Pharm. 74(4), 925-932 (2008).

    2. Niwa, S., Graf, C., and Bornancin, F. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc. Res. 77(3), 389-393 (2009).