An inhibitor of calpains
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PD 150606

Item No. 13859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-iodophenyl)-2Z-mercapto-2-propenoic acid
CAS Number
179528-45-1
Molecular Formula
C9H7IO2S
Formula Weight
306.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
λmax
259, 320 nm
SMILES
IC1=CC=C(/C=C(S)/C(O)=O)C=C1
InChi Code
InChI=1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5-
InChi Key
DJCVSFWGKYHMKH-YVMONPNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $94

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    25 mg

    $366

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    Product Description

    PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)).1 PD 150606 is commonly used to elucidate the roles for calpains in cell function, particularly in how they relate to apoptosis.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, K.K.W., Nath, R., Posner, A., et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc. Natl. Acad. Sci. USA 93, 6687-6692 (1996).

    2. Muruganandan, S., and Cribb, A.E. Calpain-induced endoplasmic reticulum stress and cell death following cytotoxic damage to renal cells. Toxicol. Sci. 94(1), 118-128 (2006).

    3. Norberg, E., Gogvadze, V., Ott, M., et al. An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ. 15, 1857-1864 (2008).

    4. Debiasi, R.L., Squier, M.K.T., Pike, B., et al. Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J. Virol. 73(1), 695-701 (1999).