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(−)-(S)-Cathinone (hydrochloride)

Item No. 13869

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-1-phenyl-1-propanone, monohydrochloride
CAS Number
72739-14-1
Molecular Formula
C9H11NO • HCl
Formula Weight
185.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
247 nm
SMILES
O=C([C@@H](N)C)C1=CC=CC=C1.Cl
InChi Code
InChI=1S/C9H11NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7H,10H2,1H3;1H/t7-;/m0./s1
InChi Key
HPZCAKYHISJOIK-FJXQXJEOSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Cathinone, the main psychoactive alkaloid from the khat plant (C. edulis), is a potent central stimulant and a naturally occurring analog of amphetamine. (−)-(S)-Cathinone is several times more potent than its (+)-isomer, and its absolute stereochemistry is identical to that of (+)-(S)-amphetamine.1 Like amphetamine, (−)-(S)-cathinone is a potent releaser of norepinephrine and dopamine from their intracellular stores.2,3 With an ED50 value of 0.42 μmol/kg, (−)-(S)-cathinone produces amphetamine-like stimulus effects in rats trained to discriminate 1 mg/kg of (+)-(S)-amphetamine from vehicle.1 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dal Cason, T.A., Young, R., and Glennon, R.A. Cathinone: An investigation of several N-alkyl and methylenedioxy-substituted analogs. Pharmacol. Biochem. Behav. 58(4), 1109-1116 (1997).

    2. Kalix, P., and Glennon, R.A. Further evidence for an amphetamine-like mechanism of action of the alkaloid cathinone. Biochem. Pharmacol. 35(18), 3015-3019 (1986).

    3. Glennon, R.A., and Liebowitz, S.M. Serotonin receptor affinity of cathinone and related analogues. J. Med. Chem. 25(4), 393-397 (1982).