A cryptochrome protein stabilizer
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KL001

Item No. 13878

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide
CAS Number
309928-48-1
Molecular Formula
C21H22N2O4S
Formula Weight
398.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:1): 0.50 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/ml
λmax
228, 235, 261, 293, 329, 343 nm
SMILES
O=S(N(CC(O)CN1C(C=CC=C2)=C2C3=C1C=CC=C3)CC4=CC=CO4)(C)=O
InChi Code
InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3
InChi Key
OQAFDLPAPSSOHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $134

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    25 mg

    $259

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    Cayman Chemical
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    Product Description

    KL001 is a cryptochrome protein stabilizer.1 It inhibits ubiquitin-induced degradation of cryptochrome 1 (CRY1) in HEK293T cells overexpressing CRY1 when used at a concentration of 50 µM. KL001 (0.3-24 µM) lengthens the circadian period in U2OS human osteosarcoma cells in a reporter assay. It reduces glucagon-induced expression of the genes encoding phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) in primary mouse hepatocytes in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hirota, T., Lee, J.W., St.John, P.C., et al. Identification of small molecule activators of cryptochrome. Science 337(6098), 1094-1097 (2012).