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3,4,5-Trimethoxyamphetamine (hydrochloride)

Item No. 13887

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Mescalamphetamine
  • NSC 167759
  • TMA
Technical Information
Formal Name
3,4,5-trimethoxy-α-methyl-benzeneethanamine, monohydrochloride
CAS Number
5688-80-2
Molecular Formula
C12H19NO3 • HCl
Formula Weight
261.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 13 mg/mlDMSO: 5 mg/mlEthanol: 14 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
COC1=C(OC)C(OC)=CC(CC(C)N)=C1.Cl
InChi Code
InChI=1S/C12H19NO3.ClH/c1-8(13)5-9-6-10(14-2)12(16-4)11(7-9)15-3;/h6-8H,5,13H2,1-4H3;1H
InChi Key
GOAXEHDWLMGWIV-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    3,4,5-Trimethoxyamphetamine (TMA), is a psychedelic hallucinogen which has appeared on the illicit drug market.1 Unlike amphetamines and cathinones, TMA has no effect on monoamine re-uptake.2 TMA has modest effects on the 5-HT2 serotonin receptors (pEC50 = 5.15 and 5.31 for phosphatidyl inositol release through 5-HT2A and 5-HT2C, respectively).3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wohlfarth, A., Weinmann, W., and Dresen, S. LC-MS/MS screening method for designer amphetamines, tryptamines, and piperazines in serum. Anal. Bioanal. Chem. 396(7), 2403-2414 (2010).

    2. Nagai, F., Nonaka, R., and Satoh Hisashi Kamimura, K. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. Eur. J. Pharmacol. 559(2-3), 132-137 (2007).

    3. Moya, P.R., Berg, K.A., Gutiérrez-Hernandez, M.A., et al. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J. Pharmacol. Exp. Ther. 321(3), 1054-1061 (2007).