Caspase-1 Monoclonal Antibody (Clone 14F468)

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.¹ The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1 is similar to the cell death gene CED-3 of C. elegans and regulates multiple proinflammatory cytokines, including interleukin-1β and interferon-γ-inducing factor.

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1. Cerretti, D.P., Kozlosky, C.J., Mosley, B., et al. Molecular cloning of the interleukin-1β converting enzyme. Science 256(5053), 97-100 (1992).