For immunochemical detection of caspase-14
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Caspase-14 Monoclonal Antibody (Clone 70A1426)

Item No. 13916

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CASP-14
  • MICE
  • Mini-interleukin-1 Converting Enzyme
Immunogen
A synthetic peptide corresponding to amino acids 2-18 of mouse caspase-14
Clone Designation
70A1426
Amino Acids
amino acids 2-18
Formulation (Request formulation change)
200 µl antibody solution with 0.09% sodium azide
Storage Buffer
Ascites with PBS
Host
Mouse
Isotype
IgG1κ
Applications
FC (intracellular), IHC, WB
Cross Reactivity
(+) Caspase-14
Species Reactivity
(+) Human(+) Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Caspase-14 is a cysteinyl aspartic protease.1,2,3 It is expressed during embryonic development and in differentiating keratinocytes and localizes to the cytoplasm and nucleus.2,3 Caspase-14 is produced as a zymogen containing a large and small subunit and is activated via proteolytic cleavage by kallikrein 7 (KLK7).4 It is involved in keratinocyte differentiation, cornification, UVB protection, and profilaggrin degradation.1 A SNP in CASP14, the gene encoding caspase-14, is associated with ichthyosis.5 Cayman’s Caspase-14 Monoclonal Antibody (Clone 70A1426) can be used for intracellular flow cytometry (FC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes caspase-14 from human and mouse samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sahoo, G., Samal, D., Khandayataray, P., et al. A review on caspases: Key regulators of biological activities and apoptosis. Mol. Neurobiol. 60(10), 5805-5837 (2023).

    2. Hu, S., Snipas, S.J., Vincenz, C., et al. Caspase-14 is a novel developmentally regulated protease. The Journal of Biological Chemisty 273(45), 29648-29653 (1998).

    3. Lippens, S., Kockx, M., Knaapen, M., et al. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. Cell Death Differ. 7(12), 1218-1224 (2000).

    4. Yamamoto, M., Miyai, M., Matsumoto, Y., et al. Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form. The Journal of Biological Chemisty 287(39), 32825-32834 (2012).

    5. Kirchmeier, P., Zimmer, A., Bouadjar, B., et al. Whole-exome-sequencing reveals small deletions in CASP14 in patients with autosomal recessive inherited ichthyosis. Acta Derm. Venereol. 97(1), 102-104 (2017).