A potent agonist of GPR35 orphan receptors
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Pamoic Acid

Item No. 13946

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid]
CAS Number
130-85-8
Synonyms
  • Embonic Acid
  • NSC 30188
  • NSC 40132
Molecular Formula
C23H16O6
Formula Weight
388.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.2 mg/mlMethanol: slightly soluble
λmax
237, 370 nm
SMILES
OC(C1=CC(C=CC=C2)=C2C(CC3=C(C=CC=C4)C4=CC(C(O)=O)=C3O)=C1O)=O
InChi Code
InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
InChi Key
WLJNZVDCPSBLRP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

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    Product Description

    Pamoic acid is a potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay).1 It induces GPR35 translocation from the plasma membrane to the cytoplasm with an EC50 value of 22 nM. Pamoic acid also increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a. In vivo, pamoic acid has antinociceptive effects with an ED50 value of 40.5 mg/kg in a mouse abdominal constriction model of visceral pain perception. Pamoate salts, of which pamoic acid is the main constituent, have been used in drug formulations to extend the duration of action.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, P., Sharir, H., Kapur, A., et al. Targeting of the orphan receptor GPR35 by pamoic acid: A potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol. Pharmacol. 78(4), 560-568 (2010).

    2. Neubig, R.R. Mind your salts: When the inactive constituent isn’t. Mol. Pharmacol. 78(4), 558-559 (2010).