A PAO inhibitor
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MDL 72527 (hydrochloride)

Item No. 13996

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N4-di-2,3-butadien-1-yl-1,4-butanediamine, dihydrochloride
CAS Number
93565-01-6
Molecular Formula
C12H20N2 • 2HCl
Formula Weight
265.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: slightlyDMSO: 0.33 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C=C=CCNCCCCNCC=C=C
InChi Code
InChI=1S/C12H20N2/c1-3-5-9-13-11-7-8-12-14-10-6-4-2/h5-6,13-14H,1-2,7-12H2
InChi Key
IKSQCMLJDHRWOA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $196

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    25 mg

    $389

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    Cayman Chemical
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    Product Description

    MDL 72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM, respectively).1 It does not inhibit monoamine oxidase or D-amino acid oxidase. MDL 72527 inhibits PAO-dependent H2O2 production in vitro and in vivo and is used to study the role of PAO activity in diverse models, including infection, cancer, and hyperoxia.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moriya, S.S., Miura, T., Takao, K., et al. Development of irreversible inactivators of spermine oxidase and N1-acetylpolyamine oxidase. Biol. Pharm. Bull. 37(3), 475-480 (2014).

    2. Chaturvedi, R., Cheng, Y., Asim, M., et al. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. The Journal of Biological Chemisty 279(38), 40161-40173 (2004).

    3. Goodwin, A.C., Destefano, C.E., Wu, S., et al. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc. Natl. Acad. Sci. USA 108(37), 15354-15359 (2011).

    4. Patel, C.A., Xu, Z., Xing, J., et al. Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy. Biochim. Biophys. Acta 1862(9), 1628-1639 (2016).