O-7460

In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC₅₀ = 690 nM).¹ It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC₅₀s > 10 µM) and does not bind to CB₁ or CB₂ cannabinoid receptors (K_is > 10 µM).¹ At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.¹

WARNING This product is not for human or veterinary use.

1. Bisogno, T., Mahadevan, A., Coccurello, R., et al. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. Br. J. Pharmacol. 169(4), 784-793 (2012).