Erucin

Erucin is an isothiocyanate derived from glucoerucin, a glucosinolate predominant in arugula (Eruca sativa Mill.) and other cruciferous vegetables. At 2.5-5 μM erucin can induce significant neuroprotective and antioxidant effects, increasing both total glutathione levels and total antioxidant capacity at the cytosolic level in dopaminergic-like neuroblastoma SH-SY5Y cells.¹ Growth inhibition, cell cycle regulation, apoptosis, and induction of detoxification enzymes have all been reported from use of erucin in prostate, lung, liver, and colon cancer cells.^2,3

WARNING This product is not for human or veterinary use.

1. Tarozzi, A., Morroni, F., Bolondi, C., et al. Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line. Int. J. Mol. Sci. 13(9), 10899-10910 (2012).

2. Melchini, A., and Traka, M.H. Biological profile of erucin: A new promising anticancer agent from cruciferous vegetables. Toxins (Basel) 2(4), 593-612 (2010).

3. Zhang, Y., Talalay, P., Cho, C.G., et al. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89(6), 2399-2403 (1992).