A neuropeptide and kisspeptin receptor ligand
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Kisspeptin-10 (mouse, rat)

Item No. 14036

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-seryl-L-phenylalanylglycyl-L-leucyl-L-arginyl-L-tyrosinamide
CAS Number
478507-53-8
Synonyms
  • Kp-10
  • YNWNSFGLRY-NH2
Molecular Formula
C63H83N17O15
Formula Weight
1318.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
O=C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)[C@@H](NC([C@H](CC(N)=O)NC([C@@H](N)CC3=CC=C(O)C=C3)=O)=O)CC4=CNC5=CC=CC=C45
InChi Code
InChI=1S/C63H83N17O15/c1-33(2)23-45(58(91)74-43(13-8-22-70-63(68)69)57(90)75-44(54(67)87)25-36-16-20-39(83)21-17-36)73-53(86)31-72-56(89)46(26-34-9-4-3-5-10-34)77-62(95)50(32-81)80-61(94)49(29-52(66)85)79-59(92)47(27-37-30-71-42-12-7-6-11-40(37)42)78
InChi Key
HVPGTDOCSYBNFC-INXYWQKQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $395

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    25 mg

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    Product Description

    Kisspeptin-10 is a neuropeptide and ligand of the kisspeptin receptor, previously known as G protein-coupled receptor 54 (GPR54).1 It corresponds to amino acids 110-119 of rodent kisspeptin-1 (KiSS1), a metastasis suppressor gene product. Kisspeptin-10 (10 µM) inhibits FGF2-induced migration of NIH3T3 cells expressing the mouse kisspeptin receptor. Intracerebroventricular administration of kisspeptin-10 increases serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in adult male rats (ED50s = 400 and 4 pmol/animal).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stafford, L.J., Xia, C., Ma, W., et al. Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 62(19), 5399-5404 (2002).

    2. Navarro, V.M., Castellano, J.M., Fernández-Fernández, R., et al. Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology 146(4), 1689-1697 (2005).