A selective inhibitor of 15-PGDH
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STK393606

Item No. 14049

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)thio]methyl]-benzonitrile
CAS Number
355827-05-3
Molecular Formula
C14H9BrN4S
Formula Weight
345.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 12 mg/ml
λmax
311 nm
SMILES
BrC1=CNC2=NC(SCC3=CC=CC=C3C#N)=NC2=C1
InChi Code
InChI=1S/C14H9BrN4S/c15-11-5-12-13(17-7-11)19-14(18-12)20-8-10-4-2-1-3-9(10)6-16/h1-5,7H,8H2,(H,17,18,19)
InChi Key
DEYMHFHACXKPOV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $242

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    10 mg

    $454

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    25 mg

    $1,053

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    Product Description

    15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) is a key enzyme involved in the inactivation of PGs and related eiscosanoids.1 It functions by catalyzing the oxidation of primary PGs to their 15-keto metabolites. Two types of 15-hydroxy PGDH have been identified: type-I is NAD+-dependent primarily using eicosanoids as substrates, while type-II uses either NAD+ or NADP+ as cofactors and bears broader substrate specificity.1 STK393606 is a competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH with an IC50 value of 26.4 nM and a Ki value of 5 nM.2 It demonstrates selectivity for 15-hydroxy PGDH when profiled across a panel of related dehydrogenase or reductase enzymes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tai, H.H., Ensor, C.M., Tong, M., et al. Prostaglandin catabolizing enzymes. Prostaglandins Other Lipid Mediat. 68-69, 483-493 (2002).

    2. Niesen, F.H., Schultz, L., Jadhav, A., et al. High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: Mechanisms of inhibition and structure-activity relationships. PLoS One 5(11), e13719 (2010).