An inhibitor of dynamin-mediated endocytosis
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Dynasore

Item No. 14062

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-2-[(3,4-dihydroxyphenyl)methylene]hydrazide-2-naphthalenecarboxylic acid
CAS Number
304448-55-3
Molecular Formula
C18H14N2O4
Formula Weight
322.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 12.5 mg/ml
SMILES
OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=CC(O)=C(O)C=C3)=O
InChi Code
InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChi Key
SYNDQCRDGGCQRZ-VXLYETTFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM).12 Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands.345 In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.67

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Macia, E., Ehrlich, M., Massol, R., et al. Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10(6), 839-850 (2006).

    2. Kirchhausen, T., Macia, E., and Pelish, H.E. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol. 438, 77-93 (2008).

    3. Chen, C.L., Hou, W.H., Liu, I.H., et al. Inhibitors of clathrin-dependent endocytosis enhance TGFβ signaling and responses. J. Cell Sci. 122, 1863-1871 (2009).

    4. Barrias, E.S., Reignault, L.C., de Souza, W., et al. Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages. PLoS One 5(1), (2010).

    5. de la Vega, M., Marin, M., Kondo, N., et al. Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion. Retrovirology 8(99), (2011).

    6. Douthitt, H.L., Luo, F., McCann, S.D., et al. Dynasore, an inhibitor of dynamin, increases the probability of transmitter release. Neuroscience 172, 187-195 (2011).

    7. Seil, M., El Ouaaliti, M., and Dehaye, J.P. Secretion of IL-1β triggered by dynasore in murine peritoneal macrophages. Innate Immun. 18(2), 241-249 (2012).

    Product Citations

    Gehne, N., Lamik, A., Lehmann, M., et al. Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops. PLoS One 12(8), e0182106 (2017).

    Trusch, F., Loebach, L., Wawra, S., et al. Cell entry of a host-targeting protein of oomycetes requires gp96. Nat. Commun. 9(1), 2347 (2018).