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25I-NBF (hydrochloride)

Item No. 14066

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 2C-I-NBF
Technical Information
Formal Name
N-(2-fluorobenzyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethanamine, monohydrochloride
CAS Number
1539266-13-1
Molecular Formula
C17H19FINO2 • HCl
Formula Weight
451.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS(pH 7.2)(1:1): 0.50 mg/mlDMSO: 12.5 mg/mlEthanol: 2 mg/ml
λmax
234, 300 nm
SMILES
IC1=CC(OC)=C(CCNCC2=C(F)C=CC=C2)C=C1OC.Cl
InChi Code
InChI=1S/C17H19FINO2.ClH/c1-21-16-10-15(19)17(22-2)9-12(16)7-8-20-11-13-5-3-4-6-14(13)18;/h3-6,9-10,20H,7-8,11H2,1-2H3;1H
InChi Key
GHAILJKILCIMFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    25I-NBF is an N-benzyl derivative of the phenethylamine hallucinogen 2C-I which acts as a highly potent partial agonist for the 5-HT2A receptor. 25I-NBF acts as a partial agonist of human 5-HT2A receptors demonstrating a Ki value of 0.26 nM and an EC50 value of 1.6 nM.1 A radiolabelled form of 25I-NBF has been used for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography.2 This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT2A receptor residues Phe3396.51 and Phe3406.52 with superpotent N-benzyl phenethylamine agonists. Mol. Pharm. 70(6), 1956-1965 (2006).

    2. Ettrup, A., Hansen, M., Santini, M.A., et al. Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers. Eur. J. Nucl. Med. Mol. Imaging 38(4), 681-693 (2011).

    Product Citations

    Sekula, K., Wrzesień-Tokarczyk, W., and Zuba, D. Analysis of the fragmentation of new-type phenethylamine derivatives from the NBOME and NBF froups under electrospray ionization conditions using high resolution mass spectrometry. Problems of Forensic Sciences 118, 157-169 (2019).