A cationic peptide antibiotic
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Polymyxin B1 Isoleucine (sulfate)

Item No. 14075

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-12-((S)-sec-butyl)-3-((R)-1-hydroxyethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide, monosulfate
Molecular Formula
C56H98N16O13 • H2SO4
Formula Weight
1301.6
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 0.3 mg/ml
SMILES
O=C([C@@H](NC([C@H](CCN)NC(CCCCC(C)CC)=O)=O)[C@@H](C)O)N[C@@H](CCN)C(N[C@@H](CCNC([C@@H](NC([C@@H](NC([C@H](CCN)N1)=O)CCN)=O)[C@H](O)C)=O)C(N[C@@H](CCN)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChi Code
InChI=1S/C56H98N16O13.H2O4S/c1-7-31(3)14-12-13-17-43(75)63-36(18-24-57)51(80)72-46(34(6)74)56(85)68-39(21-27-60)48(77)66-41-23-29-62-54(83)45(33(5)73)71-52(81)40(22-28-61)65-47(76)38(20-26-59)67-55(84)44(32(4)8-2)70-53(82)42(30-35-15-10-9-11-16-35)69-49(78)37(19-25-58)64-50(41)79;1-5(2,3)4/h9-11,15-16,31-34,36-42,44-46,73-74H,7-8,12-14,17-30,57-61H2,1-6H3,(H,62,83)(H,63,75)(H,64,79)(H,65,76)(H,66,77)(H,67,84)(H,68,85)(H,69,78)(H,70,82)(H,71,81)(H,72,80);(H2,1,2,3,4)/t31?,32-,33+,34+,36-,37-,38-,39-,40-,41-,42+,44-,45-,46-;/m0./s1
InChi Key
CTVJDEFGPKKPRM-QSEPSDMCSA-N
Origin
Bacterium/Bacillus polymyxa
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Polymyxin B1 isoleucine differs from polymyxin B1 by having isoleucine rather than leucine as a component of the cyclic peptide. Polymyxin B1 isoleucine is comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.1 Its relative pharmacokinetics and nephrotoxicity have not been examined.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tam, V.H., Cao, H., Ledesma, K.R., et al. In vitro potency of various polymyxin B components. Antimicrob. Agents Chemother. 55(9), 4490-4491 (2011).