An intermediate for purine synthesis
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SAICAR (hydrate)

Item No. 14087

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic acid, hydrate
Synonyms
  • Succino-AICAR
  • Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate
Molecular Formula
C13H19N4O12P • XH2O
Formula Weight
454.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly SolubleWater: Slightly Soluble
SMILES
NC1=C(C(N[C@H](C(O)=O)CC(O)=O)=O)N=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O2.O
InChi Code
InChI=1S/C13H19N4O12P.H2O/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27;/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27);1H2/t4-,5+,8+,9+,12+;/m0./s1
InChi Key
HDXONPSAWBEBTQ-GMXQVFHASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $423

    Add
    Cayman Chemical
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    Product Description

    SAICAR is an intermediate in the de novo purine nucleotide synthesis pathway. It is reported to stimulate pyruvate kinase isoform M2 and to promote cancer cell survival in conditions of limited glucose availability.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keller, K.E., Tan, I.S., and Lee, Y.S. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science 338(6110), 1069-1072 (2012).