An Oct4-activating compound
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OAC1

Item No. 14102

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-1H-pyrrolo[2,3-c]pyridin-5-yl-benzamide
CAS Number
300586-90-7
Molecular Formula
C14H11N3O
Formula Weight
237.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
λmax
224, 260, 301 nm
SMILES
O=C(NC1=NC=C(NC=C2)C2=C1)C3=CC=CC=C3
InChi Code
InChI=1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18)
InChi Key
HWJRIFZDXJKJJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $178

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    25 mg

    $392

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    Product Description

    OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter.1 In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.1 The iPSCs developed using OAC1 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, W., Tian, E., Chen, Z.X., et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc. Natl. Acad. Sci. USA 109(51), 20853-20858 (2012).