An Oct4-activating compound
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OAC2

Item No. 14103

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-1H-indol-5-yl-benzamide
CAS Number
6019-39-2
Molecular Formula
C15H12N2O
Formula Weight
236.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 2.5 mg/ml
λmax
202, 224, 265 nm
SMILES
O=C(NC1=CC=C(NC=C2)C2=C1)C3=CC=CC=C3
InChi Code
InChI=1S/C15H12N2O/c18-15(11-4-2-1-3-5-11)17-13-6-7-14-12(10-13)8-9-16-14/h1-10,16H,(H,17,18)
InChi Key
JCAFGYWSIWYMOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    50 mg

    $376

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    Product Description

    Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.1,2 OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.3 In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.3 The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niwa, H., Miyazaki, J.i., and Smith, A.G. Quantitative expression of Oct-¾ defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24(4), 372-376 (2000).

    2. Takahashi, K., Tanabe, K., Ohnuki, M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5), 861-872 (2007).

    3. Li, W., Tian, E., Chen, Z.X., et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc. Natl. Acad. Sci. USA 109(51), 20853-20858 (2012).