An Oct4-activating compound
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OAC3

Item No. 14104

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-fluoro-N-1H-indol-5-yl-benzamide
CAS Number
182564-41-6
Molecular Formula
C15H11FN2O
Formula Weight
254.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.50 mg/mlDMSO: 16 mg/mlEthanol: 12.5 mg/ml
λmax
224, 264 nm
SMILES
O=C(NC1=CC=C(NC=C2)C2=C1)C3=CC=C(F)C=C3
InChi Code
InChI=1S/C15H11FN2O/c16-12-3-1-10(2-4-12)15(19)18-13-5-6-14-11(9-13)7-8-17-14/h1-9,17H,(H,18,19)
InChi Key
RQJUZWRDCVBOMH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    50 mg

    $376

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    Product Description

    Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.1,2 OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.3 In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niwa, H., Miyazaki, J.i., and Smith, A.G. Quantitative expression of Oct-¾ defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24(4), 372-376 (2000).

    2. Takahashi, K., Tanabe, K., Ohnuki, M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5), 861-872 (2007).

    3. Li, W., Tian, E., Chen, Z.X., et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc. Natl. Acad. Sci. USA 109(51), 20853-20858 (2012).