Pricing updated 2019-03-24. Prices are subject to change without notice.
(±)-β-Hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs), increasing acetylation of histones in a dose-dependent manner.1 It does not increase acetylation of α-tubulin, indicating that it does not inhibit the class IIb HDAC6.1 Fasting or caloric restriction, two conditions associated with increased βOHB abundance, increases global histone acetylation in mouse tissues.1
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Shimazu, T., Hirschey, M.D., Newman, J., et al. Suppression of oxidative stress by β-