An endogenous and specific inhibitor of class I HDACs
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(±)-β-Hydroxybutyrate

Item No. 14148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-butanoic acid
CAS Number
300-85-6
Synonyms
  • 3-Hydroxybutyric Acid
  • NSC 3806
  • βOHB
Molecular Formula
C4H8O3
Formula Weight
104.1
Purity
≥95%
Formulation
Neat oil
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
210 nm
SMILES
CC(O)CC(O)=O
InChi Code
InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/t3-/m
InChi Key
WHBMMWSBFZVSSR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $53

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    5 g

    $180

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    10 g

    $332

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    Product Description

    (±)-β-Hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs), increasing acetylation of histones in a dose-dependent manner.1 It does not increase acetylation of α-tubulin, indicating that it does not inhibit the class IIb HDAC6.1 Fasting or caloric restriction, two conditions associated with increased βOHB abundance, increases global histone acetylation in mouse tissues.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimazu, T., Hirschey, M.D., Newman, J., et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211-214 (2013).