A 3β-hydroxysteroid dehydrogenase inhibitor
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Trilostane

Item No. 14164

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4α,5α-epoxy-3,17β-dihydroxy-androst-2-ene-2-carbonitrile
CAS Number
13647-35-3
Synonyms
  • Desopan
  • Modrefen
  • Vetoryl
  • WIN 24,540
Molecular Formula
C20H27NO3
Formula Weight
329.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 16 mg/ml
λmax
252 nm
SMILES
OC1=C(C#N)C[C@@]2(C)[C@@]3(CC[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@@H]5O)[C@@H]1O3
InChi Code
InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
InChi Key
KVJXBPDAXMEYOA-CXANFOAXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    50 mg

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    Product Description

    Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively.1 Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels.2 Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thomas, J.L., Mack, V.L., Glow, J.A., et al. Structure/function of the inhibition of human 3β-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane. J. Steroid Biochem. Mol. Biol. 111(1-2), 66-73 (2008).

    2. Machida, T., Uchida, E., Matsuda, K., et al. Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a dog: Case report. J. Vet. Med. Sci. 70(3), 317-320 (2008).

    3. Thomas, J.L., Bucholtz, K.M., and Kacsoh, B. Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J. Steroid Biochem. Mol. Biol. 125(1-2), 57-65 (2011).