A natural isoflavone
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Genistin

Item No. 14174

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
529-59-9
Synonyms
  • NSC 5112
Molecular Formula
C21H20O10
Formula Weight
432.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS(pH 7.2)(1:1): 0.50 mg/mlDMSO: 12.5 mg/ml
λmax
262 nm
SMILES
OC1=C(C(C(C2=CC=C(O)C=C2)=CO3)=O)C3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C1
InChi Code
InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
InChi Key
ZCOLJUOHXJRHDI-CMWLGVBASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $68

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    10 mg

    $124

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    25 mg

    $228

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    50 mg

    $418

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    Cayman Chemical
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    Product Description

    Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo.1 Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.2,3 It also increases bone formation in collagen matrix in vivo.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Allred, C.D., Ju, Y.H., Allred, K.F., et al. Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22(10), 1667-1673 (2001).

    2. Uesugi, T., Toda, T., Tsuji, K., et al. Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin. Biol. Pharm. Bull. 24(4), 368-372 (2001).

    3. Li, X.h., Zhang, J.C., Sui, S.f., et al. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol. Sin. 26(9), 1081-1086 (2005).

    4. Wong, R.W., and Rabie, A.B. Effect of genistin on bone formation. Front. Biosci. (Elite Ed.) 2(2), 764-770 (2010).