A potent agonist of D2 receptors
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B-HT 920 (hydrochloride)

Item No. 14177

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,7,8-tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d]azepin-2-amine, dihydrochloride
CAS Number
36085-73-1
Molecular Formula
C10H15N3S • 2HCl
Formula Weight
282.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
225, 263 nm
SMILES
NC(S1)=NC2=C1CCN(CC=C)CC2.Cl.Cl
InChi Code
InChI=1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H
InChi Key
DPQAXNSOFFYKDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 mg

    $75

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    10 mg

    $134

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    50 mg

    $553

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    Product Description

    B-HT 920 is a potent agonist of dopamine 2 (D2) receptors (Ki = 5.8 nM) that shows selectivity for D2 over D3 and D4 receptors.1,2,3 It has neuroprotective and regenerative effects in animal models of Parkinson’s disease.4 B-HT 920 is also an agonist of α2-adrenergic receptors and an antagonist of serotonin-3 (5-HT3; Ki = 0.35 µM) receptors.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maina, F.K., and Mathews, T.A. A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem Neurosci. 1(6), 450-462 (2010).

    2. Mewshaw, R.E., Kavanagh, J.J., Stack, G., et al. New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans. J. Med. Chem. 40(26), 4235-4256 (1997).

    3. Robertson, G.S., Tham, C.S., Wilson, C., et al. In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J. Pharmacol. Exp. Ther. 264(3), 1344-1351 (1993).

    4. Kitamura, Y. Dopaminergic neuroprotection and reconstruction of neural network tiara. Yakugaku Zasshi 130(10), 1263-1272 (2010).

    5. Nishio, H., Kohno, Y., Fujii, A., et al. 5-HT3 receptor blocking properties of the antiparkinsonian agent, talipexole. Gen. Pharmcol. 27(5), 778-785 (1996).

    6. Rocco, D., and Taira, C.A. Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen. Pharmcol. 32(1), 29-34 (1999).