An NMDA receptor antagonist
Related Products
Labeled Version(s)
25463Memantine-d6 (hydrochloride)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Memantine (hydrochloride)

Item No. 14184

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine, monohydrochloride
CAS Number
41100-52-1
Synonyms
  • Akatinol
  • Axura
  • Ebix
  • Namenda
  • NSC 102290
  • SUN Y7017
Molecular Formula
C12H21N • HCl
Formula Weight
215.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
N[C@]12C[C@](C[C@@](C)(C2)C3)(C)C[C@@H]3C1.Cl
InChi Code
InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;
InChi Key
LDDHMLJTFXJGPI-VXMZOEJHSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $29

    Add

    25 mg

    $55

    Add

    50 mg

    $82

    Add

    100 mg

    $135

    Add
    Product Description

    Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.1 It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.2 In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer's disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.3 It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, H.S.V., Pellegrini, J.W., Aggarwal, S.K., et al. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci. 12(11), 4427-4436 (1992).

    2. Wang, X., Blanchard, J., Grundke-Iqbal, I., et al. Memantine attenuates Alzheimer’s disease-like pathology and cognitive impairment. PLoS One 10(12), e0145441 (2015).

    3. Vangeliene, V., Olevska, A., and Spanagel, R. Long‐lasting effect of NMDA receptor antagonist memantine on ethanol‐cue association and relapse. J. Neurochem. 135(6), 1080-1085 (2015).

    4. Chen, Z.-Z., Yang, D.-D., Zhao, Z., et al. Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia. Life Sci. 150, 8-14 (2016).