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4-Methylamphetamine (hydrochloride)

Item No. 14215

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 4-MA
  • p-Methylamphetamine
  • para-Methylamphetamine
Technical Information
Formal Name
α,4-dimethyl-benzeneethanamine, monohydrochloride
CAS Number
41632-56-8
Molecular Formula
C10H15N • HCl
Formula Weight
185.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 20 mg/mLMethanol: 1 mg/mlPBS (pH 7.2): 10 mg/mL
λmax
213 nm
SMILES
CC(N)CC1=CC=C(C)C=C1.Cl
InChi Code
InChI=1S/C10H15N.ClH/c1-8-3-5-10(6-4-8)7-9(2)11;/h3-6,9H,7,11H2,1-2H3;1H
InChi Key
KOFSZKDEQWGBDN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    4-Methylamphetamine (4-MA) (hydrochloride) (Item No. 14215) is an analytical reference standard categorized as an amphetamine. 4-MA acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase extracellular levels of these neurotransmitters. In vitro, the potencies of 4-MA for NE and DA release are similar to those of D-amphetamine with EC50 values of 22.2 and 7.2 nM for NE and 44.1 and 8.0 nM for DA, respectively.1 4-MA is more potent than D-amphetamine at releasing serotonin (EC50s = 53.4 and 1,756 nM, respectively). In rats, 4-MA acts as an agonist at 5-HT1A receptors and induces hypothermia.2 It is found as a contaminant in amphetamine, and ingestion has been associated with severe intoxication and fatalities.3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wee, S., Anderson, K.G., Baumann, M.H., et al. Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs. J. Pharmacol. Exp. Ther. 313(2), 848-854 (2005).

    2. Rubio, M., López-Arnau, R., Pubill, D., et al. Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats. Neurosci. Lett. 590, 68-73 (2015).

    3. Blanckaert, P., van Amsterdam, J.G.C., Brunt, T.M., et al. 4-Methyl-amphetamine: A health threat for recreational amphetamine users. J. Psychopharmacol. 27(9), 817-822 (2013).