For immunochemical analysis of multiubiquitin chain
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Multiubiquitin Chain Monoclonal Antibody (Clone FK1)

Item No. 14219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
Crude preparation of polyubiquitinated-lysozyme
Clone Designation
FK1
Formulation (Request formulation change)
100 µg of affinity-purified monoclonal antibody
Storage Buffer
10 mM phosphate buffer, pH 7.4, with 0.15 M sodium chloride, and 0.1% sodium azide
Host
Mouse
Isotype
IgM
Applications
WB
Cross Reactivity
(+) Polyubiquitinated conjugates(-) Free ubiquitin(-) Monoubiquitinated conjugates
Species Reactivity
(Independent) Species
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $369

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    Product Description

    Ubiquitin is a small protein composed of 76 amino acids and having a molecular weight of 8.6 kDa. It exists in all eukaryotic cells and is responsible for numerous functions in the cell by post-translational modifications of substrate proteins (ubiquitination). This process is important to numerous cellular processes including, but not limited to, apoptosis, cell cycle and division, DNA transcription, immune response, modulation of cell surface receptors, and viral infections. Clone FK1 reacts with polyubiquitinated conjugates, but does not react with free ubiquitin or monoubiquitinated conjugates.1,2 Cayman's Multiubiquitin Chain Monoclonal Antibody (Clone FK1) can be used for Western blotting applications in species independent samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takada, K., Nasu, H., Hibi, N., et al. Serum concentrations of free ubiquitin and multiubiquitin chains. Clin. Chem. 43(7), 1188-1195 (1997).

    2. Fujimuro, M., Sawada, H., and Yokosawa, H. Production and characterization of monoclonal antibodies specific to multi-ubiquitin chains of polyubiquitinated proteins. FEBS Lett. 349(2), 173-180 (1994).