For immunochemical analysis of multiubiquitin chain
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Multiubiquitin Chain Monoclonal Antibody (Clone FK2)

Item No. 14220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
Crude preparation of polyubiquitinated-lysozyme
Clone Designation
FK2
Formulation (Request formulation change)
Affinity-purified monoclonal antibody
Storage Buffer
PBS, pH 7.2, with 0.09% sodium azide
Host
Mouse
Isotype
IgG1κ
Applications
ELISA, IHC, WB
Cross Reactivity
(-) Free ubiquitin
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $259

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    Product Description

    Ubiquitin is a small protein composed of 76 amino acids and having a molecular weight of 8.6 kD. It exists in all eukaryotic cells and is responsible for numerous functions in the cell by post-translational modifications of substrate proteins (ubiquitination). This process is important to numerous cellular processes including, but not limited to, apoptosis, cell cycle and division, DNA transcription, immune response, modulation of cell surface receptors, and viral infections. Clone FK2 is the most widely used ubiquitin antibody. This clone reacts with mono- and polyubiquitinated conjugates, but does not react with free ubiquitin.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takada, K., Nasu, H., Hibi, N., et al. Serum concentrations of free ubiquitin and multiubiquitin chains. Clin. Chem. 43(7), 1188-1195 (1997).

    2. Fujimuro, M., Sawada, H., and Yokosawa, H. Production and characterization of monoclonal antibodies specific to multi-ubiquitin chains of polyubiquitinated proteins. FEBS Lett. 349(2), 173-180 (1994).