A DR5 agonist
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Bioymifi

Item No. 14242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[5-[[3-(4-bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione
CAS Number
1420071-30-2
Molecular Formula
C22H12BrN3O4S
Formula Weight
494.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/ml
λmax
219, 267, 405 nm
SMILES
BrC(C=C1)=CC=C1N2C(S/C(C2=O)=C\C3=CC=C(C4=CC=C(C(NC5=O)=O)C5=C4)O3)=N
InChi Code
InChI=1S/C22H12BrN3O4S/c23-12-2-4-13(5-3-12)26-21(29)18(31-22(26)24)10-14-6-8-17(30-14)11-1-7-15-16(9-11)20(28)25-19(15)27/h1-10,24H,(H,25,27,28)/b18-10-,24-22?
InChi Key
ULBOWKXOFOTCMU-NLDKGBHCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $462

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    Cayman Chemical
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    Product Description

    Bioymifi directly activates DR5 (Kd = 1.2 µM; IC50 = 2 µM), inducing DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, G., Wang, X., Yu, H., et al. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat. Chem. Biol. 9, 84-90 (2012).