A plant alkaloid with anticancer activity
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Luotonin F

Item No. 14254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone
CAS Number
244616-85-1
Molecular Formula
C18H11N3O2
Formula Weight
301.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 2.5 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml
λmax
213, 255, 304 nm
SMILES
O=C1NC(C(C2=CC(C=CC=C3)=C3N=C2)=O)=NC4=CC=CC=C41
InChi Code
InChI=1S/C18H11N3O2/c22-16(12-9-11-5-1-3-7-14(11)19-10-12)17-20-15-8-4-2-6-13(15)18(23)21-17/h1-10H,(H,20,21,23)
InChi Key
HSEIGGKZBVNIDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $329

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    25 mg

    $762

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    Cayman Chemical
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    Product Description

    Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.1 It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, J.L., Cha, H.C., and Jahng, Y. Recent advances in the studies on luotonins. Molecules 16(6), 4861-4883 (2011).

    2. Cagir, A., Jones, S.H., Gao, R., et al. Luotonin A. A naturally occurring human DNA topoisomerase I poison. J. Am. Chem. Soc. 125(45), 13628-13629 (2003).

    3. Mussardo, P., Corda, E., González-Ruiz, V., et al. Study of non-covalent interactions of luotonin A derivatives and the DNA minor groove as a first step in the study of their analytical potential as DNA probes. Anal. Bioanal. Chem. 400(2), 321-327 (2011).