For immunochemical detection of GPR12
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GPR12 (N-Term) Polyclonal Antibody

Item No. 14267

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • G Protein-Coupled Receptor 12
Immunogen
Synthetic peptide from the N-terminal region of human GPR12
Formulation (Request formulation change)
Peptide affinity-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4 when reconstituted in 500 µl deionized water
Host
Rabbit
Applications
FC and ICC
Species Reactivity
(+) Human
UniProt Accession №
P47775
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 ea

    $347

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    Product Description

    G protein-coupled receptor 12 (GPR12) is a high affinity receptor for sphingosine-1-phosphate, sphingosyl-phosphorylcholine and tyrosol that is expressed in brain, pituitary, ovary, and testis tissues.1,2,3,4,5 GPR12 plays a role in neuronal differentiation, neuronal growth and the formation of synaptic contacts.2,5 Cayman’s GPR12 receptor (N-Term) polyclonal antibody can be used for flow cytometry and immunocytochemistry of GPR12 on human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Uhlenbrock, K., Gassenhuber, H., and Kostenis, E. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell. Signal. 14(11), 941-953 (2002).

    2. Ignatov, A., Lintzel, J., Hermans-Borgmeyer, I., et al. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. J. Neurosci. 23(3), 907-914 (2003).

    3. Lin, Z.J., Lu, X.M., Zhu, T.J., et al. GPR12 selections of the metabolites from an endophytic Streptomyces sp. associated with Cistanches deserticola. Arch. Pharm. Res. 31(9), 1108-1114 (2008).

    4. Eidne, K.A., Zabavnik, J., Peters, T., et al. Cloning, sequencing and tissue distribution of a candidate G protein-coupled receptor from rat pituitary gland. FEBS Lett. 292(1-2), 243-248 (1991).

    5. Tanaka, S., Ishii, K., Kasai, K., et al. Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth. The Journal of Biological Chemisty 282(14), 10506-10515 (2007).