A low-affinity calmodulin antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

W-5 (hydrochloride)

Item No. 14271

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(6-aminohexyl)-1-naphthalenesulfonamide, monohydrochloride
CAS Number
61714-25-8
Molecular Formula
C16H22N2O2S • HCl
Formula Weight
342.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 0.33 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
223, 289 nm
SMILES
O=S(C1=CC=CC2=CC=CC=C21)(NCCCCCCN)=O.Cl
InChi Code
InChI=1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
InChi Key
HOCSVIGHWPLMFC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $68

    Add

    25 mg

    $179

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    W-5 is a chlorine-deficient analog of W-7 (Item No. 14826), a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities (Ki = 11 μM).1,2 W-5 is less active than its calmodulin antagonist counterpart, inhibiting CHO-K1, MCF-7 breast cancer, and human myeloid progenitor cell proliferation with IC50 values greater than 100 μM.1,3,4 As a weaker antagonist for calmodulin, W-5 is suitable for use as a control compound for understanding the specificity of other calmodulin antagonists.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hidaka, H., Sasaki, Y., Tanaka, T., et al. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc. Natl. Acad. Sci. USA 78(7), 4354-4357 (1981).

    2. Tanaka, T., and Hidaka, H. Hydrophobic regions function in calmodulin-enzyme(s) interactions. The Journal of Biological Chemisty 255(23), 11078-11080 (1980).

    3. Gulino, A., Barrera, G., Vacca, A., et al. Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells. Cancer Res. 46, 6274-6278 (1986).

    4. Katayama, N., Nishikawa, M., Komada, F., et al. A role for calmodulin in the growth of human hematopoietic progenitor cells. Blood 75(7), 1446-1454 (1990).