A neuroprotective natural product
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Bilobalide

Item No. 14272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,5aR,8aS)-9R-(1,1-dimethylethyl)-10,10aS-dihydro-8R,9-dihydroxy-4H,5aH,9H-furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione
CAS Number
33570-04-6
Molecular Formula
C15H18O8
Formula Weight
326.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
O=C(O1)[C@H](O)C2([C@@H]1O3)[C@](O)(C(C)(C)C)C[C@H]4[C@@]2(CC(O4)=O)C3=O
InChi Code
InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15?/m0/s1
InChi Key
MOLPUWBMSBJXER-ISSLQHLCSA-N
Origin
Plant/Ginkgo biloba L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $65

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    50 mg

    $277

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    100 mg

    $455

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    Product Description

    Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage.1 Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions.2,3 It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Defeudis, F.V. Bilobalide and neuroprotection. Pharmacol. Res. 46(6), 565-568 (2002).

    2. Kiewert, C., Kumar, V., Hildmann, O., et al. Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide. Brain Res. 1201, 143-150 (2008).

    3. Lang, D., Kiewert, C., Mdzinarishvili, A., et al. Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo. Brain Res. 1425, 155-163 (2011).

    4. Lau, A.J., Yang, G., Rajaraman, G., et al. Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor. Drug Metab. Dispos. 40(1), 178-186 (2012).

    5. Deng, Y., Bi, H.C., Zhao, L.Z., et al. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica 38(5), 465-481 (2008).