An antibiotic used in tissue culture studies
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Neomycin (sulfate)

Item No. 14287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
neomycin, trisulfate salt
CAS Number
1405-10-3
Molecular Formula
C23H46N6O13 • 3H2SO4
Formula Weight
908.9
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=S(O)(O)=O.O=S(O)(O)=O.O=S(O)(O)=O.N[C@@H]1[C@@H](O[C@@H]2[C@H](N)[C@@H](O)[C@H](O)[C@@H](CN)O2)[C@H](O[C@H]3[C@H](O)[C@H](O[C@@H]4[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C1
InChi Code
InChI=1S/C23H46N6O13.3H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,1
InChi Key
KWBUARAINLGYMG-JGMIRXPNSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Neomycin is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes.1 It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release.2 Neomycin has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 µM).3 It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wilson, D.N. The A-Z of bacterial translation inhibitors. Crit. Rev. Biochem. Mol. Biol. 44(6), 393-433 (2009).

    2. Vergara, J., Tsien, R.Y., and Delay, M. Inositol 1,4,5-trisphosphate: A possible chemical link in excitation-contraction coupling in muscle. Proc. Natl. Acad. Sci. USA 82(18), 6352-6356 (1985).

    3. Liscovitch, M., Chalifa, V., Danin, M., et al. Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem. J. 279(1), 319-321 (1991).